webOS skill level: Beginner
This is a good article on Prototype and AJAX:
For an overview of how Prototype extends the DOM, read this article:
Or if you prefer to get into the nuts and bolts, the full API Documentation:
Prototype also supports a number of UI controls and widgets. How many of these will actually be supported in webOS (if any) remains to be seen. Mojo may provide a similar set of widgets that provide superior performance because they could be supported by the hardware (e.g. hardware graphics acceleration).
In terms of the application performance you might expect when using the Prototype framework, it looks like Prototype is not one of the faster frameworks out there. So keep this in mind if you intend to rely heavily on the Prototype framework in your applications.
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